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à¨ÁÊì ËÅÕè (James Li) ¼ÙéÃèÇÁ¡è͵Ñé§ »Ãиҹ¡ÃÃÁ¡Òà áÅЫÕÍÕâͧ͢਴ѺºÅÔÇ à·ÍÃÒ¾ÔǵԡÊì ¡ÅèÒÇÇèÒ "ÁÐàÃ秪¹Ô´à»ç¹¡é͹à»ç¹ÊèǹÊӤѭ㹡ÅÂØ·¸ì¡ÅØèÁ¼ÅÔµÀѳ±ì¢Í§à¨´ÑººÅÔÇ à·ÍÃÒ¾ÔǵԡÊì àÃÒ¹Óá¾Åµ¿ÍÃìÁà·¤â¹âÅÂÕáÅСÒþѲ¹Ò¼ÅÔµÀѳ±ìÁÒãªé â´Â¢³Ð¹Õé¡ÓÅѧ¾Ñ²¹Ò¼ÅÔµÀѳ±ìà«ÅÅìÀÙÁÔ¤ØéÁ¡Ñ¹ºÓºÑ´·ÕèÁÕ¤ÇÒÁ¡éÒÇÅéÓ à¾×èÍÃѺÁ×͡ѺÁÐàÃ秪¹Ô´à»ç¹¡é͹·Õ辺ä´éºèÍÂ㹨չ áÅмÅÑ¡´Ñ¹¼ÅÔµÀѳ±ì·ÕèÍÂÙèÃÐËÇèÒ§¡ÒþѲ¹ÒãËé¶Ö§¢Ñ鹡Ò÷´Åͧ·Ò§¤ÅÔ¹Ô¡"
 
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1.  肝细胞癌免疫治疗中 国专家共识,2021年,&#20 013;华医学杂志2021 年12月28日第101 卷第48期
2.  Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. ACS journals. 2021, 71(3):209-249
3.  CSCO原发性肝癌诊疗指&#21 335;,2020年, 中国临床肿瘤学会指 南工作委员会,人民 卫生出版社
 
à¡ÕèÂǡѺ JWATM204
 
JWATM204 ÁÕÊÑÁ¾ÃäÀÒ¾áÅФÇÒÁ¨Óà¾ÒТͧâÁâ¹â¤Å¹ÍÅá͹µÔºÍ´Õ GPC-3 ã¹ÃдѺÊÙ§ ¾Ñ²¹Ò¢Öé¹·Õèá¾Åµ¿ÍÃìÁ·Õ-à«ÅÅì ARTEMIS(R) ãËéà»ç¹ÀÙÁÔ¤ØéÁ¡Ñ¹ºÓºÑ´ÃÑ¡ÉÒâ´Âãªé·Õ-à«ÅÅìºÓºÑ´ «Öè§ÁØè§à»éÒä»·Õè¡ÅÑ»Ô᤹·ÃÕ (GPC-3) â´Â¡ÅÑ»Ô᤹·ÃÕÍÂÙèã¹µÃСÙÅâ»ÃµÔâÍä¡Å᤹àÂ×èÍËØéÁÀÒÂã¹·ÕèÁÕ¤ÇÒÁÊÑÁ¾Ñ¹¸ì¡ Ѻ¡ÅÑ»Ô᤹ «Öè§áÊ´§ÍÍ¡ÁÒ¡¼Ô´»¡µÔã¹âäÃéÒÂËÅÒ¡ÅØèÁ ÃÇÁ¶Ö§ÁÐàÃç§à«ÅÅìµÑº áµèäÁèáÊ´§ÍÍ¡ËÃ×ÍáÊ´§ÍÍ¡¹éÍÂÁÒ¡ã¹ÍÇÑÂÇл¡µÔ ÃÇÁ¶Ö§ÍÇÑÂÇеѺ»¡µÔËÃ×͵Ѻá¢ç§ ¡ÅÑ»Ô᤹·ÃÕáÊ´§ÍÍ¡ã¹ 72% ¢Í§¼Ùé»èÇÂÁÐàÃç§à«ÅÅìµÑº[1] â´ÂÁռšèÍÁÐàÃ秼èÒ¹¡Ãкǹ¡Òà Wnt pathway[2] ¡ÅÑ»Ô᤹·ÃÕä´é¡ÅÒÂà»ç¹à»éÒËÁÒÂËÅÑ¡¢Í§ÁÐàÃç§à«ÅÅìµÑº à¾ÃÒÐÁÕ¤ÇÒÁÍè͹äËÇáÅФÇÒÁ¨Óà¾ÒÐÊÙ§ ¢³Ð·Õèá¾Åµ¿ÍÃìÁ·Õà«ÅÅì ARTEMIS(R) «Öè§ÁÕ¡Å䡤Ǻ¤ØÁÀÒÂã¹à«ÅÅì·Õè¤ÅéÒ¡Ѻà«ÅÅìºÓºÑ´áºº TCR-T áÅÐÁÒ¾ÃéÍÁ¤ÇÒÁáÁè¹ÂÓàËÁ×͹¡Ñº¡ÒÃÃÑ¡ÉÒ´éÇ CAR-T ¹Ñé¹ ¤Ò´ÇèÒ¨Ðà¢éÒÁÒªèÇÂÅ´ËÃ×͡ӨѴ¡ÅØèÁÍÒ¡Òèҡ¡ÒÃËÅÑè§ä«âµä¤¹ì (CRS) ·ÕèÁÕ¤ÇÒÁÊÑÁ¾Ñ¹¸ì¡Ñº¡ÒáÃеØé¹ãËéà¡Ô´·Õà«ÅÅìÁÒ¡à¡Ô¹ä»áÅФÇÒÁà»ç¹¾ÔÉÍ×è¹ æ ·ÕèÊÑÁ¾Ñ¹¸ì¡Ñºä«âµä¤¹ìáÅÐÃéÒÂáç¶Ö§ªÕÇÔµä´é â´ÂâÁàÅ¡ØÅÃèÇÁẺ co-stimulatory º¹¾×é¹¼ÔǢͧ·Õà«ÅÅì ·ÓãËéÊÃéÒ§ÊÑ­­Ò³¡ÃеØé¹·Õà«ÅÅìä´éà¾Õ§¾Í «Ö觪èÇÂÊè§àÊÃÔÁ¡ÒáÃеØé¹·Õà«ÅÅìáÅзÓãËéÄ·¸ÔìµéÒ¹à¹×éͧ͡à¢éÁá¢ç§¢Öé¹
 
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1.  Capurro M, Wanless IR, Sherman M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97.
2.  Kolluri A and Ho M. The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer. Front. Oncol. 2019, 9:708.
 
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¢éͤÇÒÁ¤Ò´¡ÒóìÅèǧ˹éÒÁÒ¨Ò¡¤ÇÒÁ¤Ò´ËÇѧáÅФÇÒÁàª×èÍ㹻Ѩ¨ØºÑ¹¢Í§½èÒºÃÔ¡ Òà â´ÂÁÕ¤ÇÒÁàÊÕè§ ¤ÇÒÁäÁèá¹è¹Í¹ áÅÐÊÁÁµÔ°Ò¹ÁÒ¡ÁÒ ·ÕèÍÒ¨·ÓãËé¼ÅÅѾ¸ì¨ÃԧᵡµèÒ§ä»ÍÂèÒ§ÁÒ¡¨Ò¡·ÕèÃкØäÇé ¢éͤÇÒÁ¤Ò´¡ÒóìÅèǧ˹éÒ»ÃСͺ´éǤÇÒÁàÊÕè§áÅФÇÒÁäÁèá¹è¹Í¹ÁÒ¡ÁÒ «Öè§ÃÇÁ¶Ö§·ÕèÃкشéÒ¹ÅèÒ§ áÅÐÁÕ¡ÒÃ͸ԺÒÂà¾ÔèÁàµÔÁã¹ÃÒ§ҹ·ÕèºÃÔÉÑ·Â×è¹µè͵ÅÒ´ËØé¹Îèͧ¡§ (HKEX) ºÃÔÉÑ·ãËé¢éÍÁÙŹÕé ³ Çѹ·Õèà¼Âá¾Ãèà·èÒ¹Ñé¹ Â¡àÇé¹ÇèÒ¨ÐÃкØà»ç¹ÍÂèÒ§Í×è¹ áÅÐäÁèÁÕ¢éͼ١¾Ñ¹ã¹¡ÒûÃѺ»Ãا¢éÍÁÙÅ·ÕèÃкØã¹¢èÒÇ·Õèà¼Âá¾ÃèáÅТéÍÁÙÅÍ×è¹  æ ·Õèà¡ÕèÂÇ¢éͧ ËÃ×ÍãËé¤Ó͸ԺÒÂã´ æ ´Ù¢éÍÁÙÅà¾ÔèÁàµÔÁä´é·ÕèàÇçºä«µì¢Í§ºÃÔÉÑ www.jwtherapeutics.com/en/forward-looking-statements/
 
[1] ALLEMANI C, WEIR HK, CARREIRA H, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25, 676, 887 patients from 279 population-based registries in 67countries (CONCORD-2) . Lancet, 2015, 385: 977-1010.
[2] TORRE LA, BRAY F, SIEGEL RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65: 87-108.
 
 
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